The characteristics of sulfate-resistant cement, the composition of clinker minerals and the grindability of sulfate-resistant cement were analyzed. The application of TRMK3621 roller mill final grinding system in grinding sulfate-resistant cement was introduced. TRMK3621 type roller mill changes the traditional flat disc structure into a slightly angled swash plate, increases the width of the grinding area, and has strong material adaptability. Sulfate-resistant cement is more difficult to grind than ordinary Portland cement. TRMK3621 roller mill is used to grind sulfate-resistant cement clinker. The system runs stably and is easy to operate. The output is over 95t/h, the specific surface area is 330m2/kg, and the power consumption is 32kW·h/t.