A high-efficiency simulation tool for the V-type powder separator was developed using the PIC (Particle-in-Cell) method within the OpenFOAM open-source software. The tool was validated for its high accuracy and reliability in predicting pressure drop and particle classification efficiency in V-type powder separators. Single-factor studies revealed that the dispersion plate primarily affects the equipment’s pressure drop, while the classification plate significantly impacts particle classification efficiency. Increasing the inlet air velocity effectively enhances classification efficiency but also leads to a higher pressure drop. Multi-factor analysis identified two optimization pathways: adjusting the dispersion plate angle and closure state to minimize energy consumption, and optimizing the classification plate angle and spacing to maximize classification efficiency. This study enabled the customized development of a simulation model, providing a crucial technological foundation for reducing dependence on foreign technologies and achieving independent control over simulation tools.