Abstract: Taking a limestone quarry as the research object, the 3D geological deposit database and block model were built by Surpac software. Based on the principles of geostatistical analyst, the structure model of the reasonable variation function is built after basic statistical analysis and spatial autocorrelation of regionalized variable research through the spatial interpolation method. The grade and reserves of the deposit are estimated with the Ordinary Kriging method. Grade variation of the ore body in Z direction is drawn and used to verify and evaluate the model itself. The verifying result shows that the model is reliable and the estimation is relatively accurate which is structured and estimated by Ordinary Kriging. The Ordinary Kriging method can provide scientific grade estimation for the future development of the deposit.