The effects of mixed limestone powder and fly ash, mixed limestone powder and slag powder on the workability and compressive strength of C60 machine-made sand high-strength concrete and the optimum mix ratio were studied. By adding limestone powder and fly ash, or adding limestone powder and slag powder, the impermeability grade of C60 machine-made sand high-strength concrete is greater than P12, and the frost resistance meets the requirements of F100 frost resistance grade. Compared with the concrete paste mixed with slag powder, the concrete paste mixed with fly ash has smaller self-shrinkage at early stage and higher carbonation resistance.