To address the disposal challenge of arsenic-containing desulfurization gypsum（a hazardous waste）, industrial co-processing experiments were carried out based on a 4 500t/d new dry-process cement kiln. Three feeding rates of 5t/d, 7t/d and 9t/d were set up to systematically explore the influence of arsenic-containing desulfurization gypsum on clinker quality, heavy metal solidification, kiln tail flue gas emission and cement performance. The results indicate that when the daily feeding rate is controlled within 9t/d, the arsenic content in clinker does not exceed the national standard limit, and the leachable arsenic content is lower than the detection limit, which meets environmental protection specifications. The sulfur trioxide content of clinker increases slightly with a slight extension of setting time, while the 3d and 28d compressive strengths are improved steadily. The emission concentrations of sulfur dioxide and arsenic in kiln tail flue gas are stable and up to standard. Calculated at 9t/d, the effective raw material replacement rate reaches 0.39%, reducing 3.37kg of carbon dioxide emission per ton of clinker. This technology can realize the harmless disposal and resource utilization of arsenic-containing hazardous waste while ensuring stable kiln operation and product quality , and effectively broaden the application scope of co-processing hazardous wastes in cement kilns.